Polypeptide-Hydantoins
نویسندگان
چکیده
منابع مشابه
Regioselective multicomponent sequential synthesis of hydantoins.
The development of new practical and green methods for the synthesis of small heterocycles is an attractive area of research due to the well-known potential of heterocyclic small molecule scaffolds in the drug discovery process. Herein we report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins, in high yields and very mild ...
متن کاملThe Echanism of the Formation of Hydantoins
Demineralization of coals and coal-derived chars is part of an effort to developalternative fuels from coal. Pyrolysis and some gasification processes yieldchars containing a large fraction of the calorific value of the feed coal andessentially all of its mineral matter. In the work reported here, three gasifi-cation chars produced from anthracite, bituminous, and subbitumin...
متن کاملSynthesis of substituted hydantoins in low melting mixtures.
A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting L-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.
متن کاملFacile one-pot synthesis of 5-substituted hydantoins.
5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(III) triflate-catalysed procedure that is compatible with a range of substrates and solvents.
متن کاملDomino synthesis of 1,3,5-trisubstituted hydantoins: a DFT study.
The mechanism of the reaction between carbodiimides and activated α,β-unsaturated carboxylic acids yielding fully substituted hydantoins and variable amounts of N-acyl urea by-products was studied using density functional theory calculations. Two alternative pathways featuring N-acyl ureas and imino-oxazolidinones as intermediates for the formation of the hydantoin product were taken into accou...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1916
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2.2.69